Kainate Receptor Signaling in Pain Pathways
نویسندگان
چکیده
منابع مشابه
Kainate receptor signaling in pain pathways.
Receptors and channels that underlie nociceptive signaling constitute potential sites of intervention for treatment of chronic pain states. The kainate receptor family of glutamate-gated ion channels represents one such candidate set of molecules. They have a prominent role in modulation of excitatory signaling between sensory and spinal cord neurons. Kainate receptors are also expressed throug...
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RATIONALE Glutamate is a major signaling molecule that binds to glutamate receptors including the ionotropic glutamate receptors; kainate (KA) receptor (KAR), the N-methyl-d-aspartate receptor, and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Each is well characterized in the central nervous system, but glutamate has important signaling roles in peripheral tissues as w...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2012
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.112.081398